Clementson Group

Total synthesis, method development and chemical biology

Publications

Prior to Independent Research at Lund University

  • Paulsen, F.; Clementson, S.; Von Wachenfeldt, H.; Antoszczak, M.; Fridolf, S.; Strand, D. Synthesis of Siphonazole B Through Domino Cycloisomerization‐Oxazolonium Ion Rearrangements. Chem. – Eur. J. 2025, 31 (40), e202501394. https://doi.org/10.1002/chem.202501394.
  • Laudadio, G.; Neigenfind, P.; Péter, Á.; Rubel, C. Z.; Emmanuel, M. A.; Oderinde, M. S.; Ewing, T. E.; Palkowitz, M. D.; Sloane, J. L.; Gillman, K. W.; Ridge, D.; Mandler, M. D.; Bolduc, P. N.; Nicastri, M. C.; Zhang, B.; Clementson, S.; Petersen, N. N.; Martín‐Gago, P.; Mykhailiuk, P.; Engle, K. M.; Baran, P. S. Nickel‐Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers**. Angew. Chem. Int. Ed. 2024, 63 (8), e202314617. https://doi.org/10.1002/anie.202314617.
  • Zhang, B.; He, J.; Gao, Y.; Levy, L.; Oderinde, M. S.; Palkowitz, M. D.; Dhar, T. G. M.; Mandler, M. D.; Collins, M. R.; Schmitt, D. C.; Bolduc, P. N.; Chen, T.; Clementson, S.; Petersen, N. N.; Laudadio, G.; Bi, C.; Kawamata, Y.; Baran, P. S. Complex Molecule Synthesis by Electrocatalytic Decarboxylative Cross-Coupling. Nature 2023, 623 (7988), 745–751. https://doi.org/10.1038/s41586-023-06677-2.
  • Sofiadis, M.; Xu, D.; Rodriguez, A. J.; Nissl, B.; Clementson, S.; Petersen, N. N.; Baran, P. S. Convergent Total Synthesis of (−)-Cyclopamine. J. Am. Chem. Soc. 2023, 145 (40), 21760–21765. https://doi.org/10.1021/jacs.3c09085.
  • Pedersen, S. K.; Clementson, S.; El‐Chami, K.; Kristensen, J. L.; Jessing, M. Overcoming Energy Transfer for the Metallophotoredox Catalyzed Decarboxylative Alkenylation between Alkylcarboxylic Acids and Enol Triflates. Chem. – Eur. J. 2023, 29 (35), e202300265. https://doi.org/10.1002/chem.202300265.
  • Palkowitz, M. D.; Laudadio, G.; Kolb, S.; Choi, J.; Oderinde, M. S.; Ewing, T. E.-H.; Bolduc, P. N.; Chen, T.; Zhang, H.; Cheng, P. T. W.; Zhang, B.; Mandler, M. D.; Blasczak, V. D.; Richter, J. M.; Collins, M. R.; Schioldager, R. L.; Bravo, M.; Dhar, T. G. M.; Vokits, B.; Zhu, Y.; Echeverria, P.-G.; Poss, M. A.; Shaw, S. A.; Clementson, S.; Petersen, N. N.; Mykhailiuk, P. K.; Baran, P. S. Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis. J. Am. Chem. Soc. 2022, 144 (38), 17709–17720. https://doi.org/10.1021/jacs.2c08006.
  • Clementson, S.; Matheu, S. A.; Rørsted, E. M.; Pedersen, H.; Jensen, A. A.; Clausen, R. P.; Vital, P.; Glibstrup, E.; Jessing, M.; Kristensen, J. L. Erythrina Alkaloid Analogues as nAChR Antagonists–A Flexible Platform for Leads in Drug Discovery. J. Org. Chem. 2021, 86 (12), 8248–8262. https://doi.org/10.1021/acs.joc.1c00707.
  • Clementson, S.; Jessing, M.; Vital, P. J.; Kristensen, J. L. Development of a Divergent Route to Erythrina Alkaloids. Synlett 2020, 31 (04), 327–333. https://doi.org/10.1055/s-0039-1690792.
  • Clementson, S.; Jessing, M.; Pedersen, H.; Vital, P.; Kristensen, J. L. Enantioselective Total Synthesis of (+)-Dihydro-β-Erythroidine. J. Am. Chem. Soc. 2019, 141 (22), 8783–8786. https://doi.org/10.1021/jacs.9b04626.
  • Clementson, S.; Radaelli, A.; Fjelbye, K.; Tanner, D.; Jessing, M. Strain-Release Driven Cycloadditions for Rapid Construction of Functionalized Pyridines and Amino Alcohols. Org. Lett. 2019, 21 (12), 4763–4766. https://doi.org/10.1021/acs.orglett.9b01652.
  • Willén, D.; Bengtsson, D.; Clementson, S.; Tykesson, E.; Manner, S.; Ellervik, U. Synthesis of Double-Modified Xyloside Analogues for Probing the β4GalT7 Active Site. J. Org. Chem. 2018, 83 (3), 1259–1277. https://doi.org/10.1021/acs.joc.7b02809.
  • Thorsheim, K.; Clementson, S.; Tykesson, E.; Bengtsson, D.; Strand, D.; Ellervik, U. Hydroxylated Oxanes as Xyloside Analogs for Determination of the Minimal Binding Requirements of β4GalT7. Tetrahedron Lett. 2017, 58(35), 3466–3469. https://doi.org/10.1016/j.tetlet.2017.07.078.